Fundamental studies on a new antitumor antibiotic peplomycin.

Results of testing in mice and rats revealed that peplomycin has a stronger antitumor effect than bleomycin (BLM). Peplomycin, a BLM analogue, also has superior organ distribution characteristics and localizes in the rat prostate. Pulmonary toxicity associated with peplomycin therapy is less severe than that which accompanies BLM therapy.