Darr M, Hamburger S, Ellerbeck E
South Med J. 1982 May;75(5):627-8. doi: 10.1097/00007611-198205000-00037.
We report a patient with tuberculosis treated with a five-drug regimen who experienced severe acid-base and electrolyte abnormalities including hypomagnesemia, hypokalemia, hypocalcemia, and a hypochloremic metabolic alkalosis. These disturbances are believed to be due to treatment with capreomycin, which produced renal magnesium wasting and possible tubular damage. Therefore, we recommend frequent determinations of serum electrolytes, magnesium, and calcium in patients treated with capreomycin.
我们报告了一名采用五药联合方案治疗的结核病患者，该患者出现了严重的酸碱和电解质异常，包括低镁血症、低钾血症、低钙血症和低氯性代谢性碱中毒。据信这些紊乱是由卷曲霉素治疗所致，卷曲霉素导致了肾脏镁流失以及可能的肾小管损伤。因此，我们建议对接受卷曲霉素治疗的患者频繁测定血清电解质、镁和钙。
