卷曲霉素引起的血清电解质异常。
Capreomycin-induced serum electrolyte abnormalities.
作者信息
Holmes A M, Hesling C M, Wilson T M
出版信息
Thorax. 1970 Sep;25(5):608-11. doi: 10.1136/thx.25.5.608.
Abstract
Gross electrolyte disturbances including hypokalaemia, hypomagnesaemia, hypocalcaemia, and alkalosis have developed in tuberculous patients who were being treated with capreomycin. Similar abnormalities have also occurred when the drug gentamicin was used and were found to be due to secondary hyperaldosteronism. In this paper a detailed description of the changes induced by capreomycin is given. The evidence available strongly suggests a similar aetiology for the biochemical changes, but the precise pathophysiology is unknown. Caution should be exercised when capreomycin is used and the drug should be withdrawn if any of these abnormalities develop.
摘要
接受卷曲霉素治疗的结核病患者出现了包括低钾血症、低镁血症、低钙血症和碱中毒在内的严重电解质紊乱。使用庆大霉素时也出现了类似异常，发现这是由继发性醛固酮增多症引起的。本文详细描述了卷曲霉素引起的变化。现有证据强烈表明这些生化变化的病因相似，但确切的病理生理学尚不清楚。使用卷曲霉素时应谨慎，如果出现任何这些异常情况，应停药。
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