Erjavec F
Agents Actions. 1982 Apr;12(1-2):81-5. doi: 10.1007/BF01965110.
Histamine release by compound 48/80 was studied in vivo and in vitro in different tissues of the cat and rat. A good correlation was fond between both kinds of experiment. The histamine stores in the cat salivary gland are poorly sensitive to this histamine-liberating substance. In vitro studies with heart and lungs of the rat and guinea pig showed no correlation between the spontaneous histamine release and the release induced by compound 48/80. This finding suggests the existence of two pools of tissue histamine, both with different storage and release properties, and most probably with different functions in the body.
在猫和大鼠的不同组织中，对化合物48/80诱导的组胺释放进行了体内和体外研究。两种实验之间发现了良好的相关性。猫唾液腺中的组胺储存对这种组胺释放物质的敏感性较差。对大鼠和豚鼠的心脏和肺进行的体外研究表明，自发组胺释放与化合物48/80诱导的释放之间没有相关性。这一发现表明存在两种组织组胺池，它们具有不同的储存和释放特性，并且很可能在体内具有不同的功能。
