McKimm-Breschkin J L, Rapp F
Intervirology. 1981;16(4):250-9. doi: 10.1159/000149274.
Interferon induction in BSC-1 cells by measles virus isolates previously found to be interferon inducing (IF+) or interferon noninducing (IF-) was studied in different cell types. Lack of induction by the IF- viruses was not due to an inhibitory factor since BSC-1 cells coinfected with IF+ and IF- stocks produced interferon levels similar to those infected with IF+ stocks alone. Various tests indicated that the phenotypic expression of interferon induction by these isolates was dependent on an infectious virus genome, the cell type tested, and the passage history of the virus. In contrast to the in vitro results, the IF- phenotype was stable in vivo, whereas passage of the IF+ virus resulted in selection against the IF+ phenotype. The phenotypic expression of interferon induction by measles virus was, therefore, controlled by complex interactions between virus and host cell factors exerted both in vivo and in vitro.
在不同细胞类型中研究了先前发现具有干扰素诱导作用（IF+）或无干扰素诱导作用（IF-）的麻疹病毒分离株对BSC-1细胞的干扰素诱导情况。IF-病毒缺乏诱导作用并非由于抑制因子，因为同时感染IF+和IF-毒株的BSC-1细胞产生的干扰素水平与仅感染IF+毒株的细胞相似。各种试验表明，这些分离株干扰素诱导的表型表达取决于感染性病毒基因组、所测试的细胞类型以及病毒的传代历史。与体外结果相反，IF-表型在体内是稳定的，而IF+病毒传代导致对IF+表型的选择。因此，麻疹病毒干扰素诱导的表型表达受病毒与宿主细胞因子在体内和体外复杂相互作用的控制。
