猿猴泡沫病毒的体外干扰素诱导能力及干扰素敏感性研究。
Studies on in vitro interferon induction capacity and interferon sensitivity of simian foamy viruses.
作者信息
Rhodes-Feuillette A, Saal F, Lasneret J, Santillana-Hayat M, Peries J
机构信息
Laboratoire de Virologie des Leucémies, CNRS, Centre Hayem, Hôpital Saint Louis, Paris, France.
出版信息
Arch Virol. 1987;97(1-2):77-84. doi: 10.1007/BF01310735.
We demonstrate that Simian Foamy viruses (SFV) types 1, 2, 4 and 10 do not induce Interferon (IFN) production in mouse and primate (simian and human) cell lines, but that their cytopathogenic effect is blocked by this viral inhibitor. The mechanisms of action of IFN seems to be different from that of other Retroviridae. No trapping of virions appears in treated cells examined by ectron microscopy. Moreover, neither precursor nor mature virus particles were observed in infected cultures submitted to IFN treatment.
我们证明，猿猴泡沫病毒（SFV）1型、2型、4型和10型在小鼠和灵长类（猿猴和人类）细胞系中不会诱导干扰素（IFN）产生，但它们的细胞病变效应会被这种病毒抑制剂阻断。IFN的作用机制似乎与其他逆转录病毒科不同。通过电子显微镜检查，在处理过的细胞中未发现病毒粒子的捕获现象。此外，在接受IFN处理的感染培养物中，未观察到前体病毒粒子或成熟病毒粒子。
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