Mayer S, Tongio M M, Falkenrodt A, Pfeiffer B, Bergerat J P
J Immunogenet. 1982 Apr;9(2):111-20. doi: 10.1111/j.1744-313x.1982.tb00970.x.
Virus infected cells can carry HLA antigens not demonstrated in uninfected cells. In a wider context, it is known that tumour cells in the mouse can exhibit H2-like antigens of foreign haplotypes which they resemble. Our aim was to investigate, using an absorption method, the HLA antigens of ten leukaemic cells and to compare these results with those of normal lymphocytes. The following sera was used for absorption: anti-B5 serum, anti-B7 serum, anti-B12 serum. These sera were absorbed on the ten leukaemic cells and fifteen healthy lymphocytes. An anti-A1 + B8 serum and an anti-A2 serum were absorbed on the ten leukaemic cells, but there was not enough serum to carry out the similar absorption with the healty lymphocytes. Two points emerged from these results. (1) Leukaemia cells absorbed anti-HLA antibodies as effectively as healthy lymphocytes when the cells carried the antigen corresponding to the serum specificity. The curves obtained with leukaemia cells were comparable to those of healthy cells. (2) When the cells were not carriers of the antigens corresponding to the antibody's specificity, leukaemia cells were also capable of absorbing antibodies, unlike healthy lymphocytes which had no or poor absorption.
病毒感染的细胞可携带未感染细胞中未表现出的HLA抗原。在更广泛的背景下，已知小鼠中的肿瘤细胞可表现出与其相似的外来单倍型的H2样抗原。我们的目的是使用吸收法研究10个白血病细胞的HLA抗原，并将这些结果与正常淋巴细胞的结果进行比较。使用以下血清进行吸收：抗B5血清、抗B7血清、抗B12血清。这些血清在10个白血病细胞和15个健康淋巴细胞上进行吸收。一种抗A1 + B8血清和一种抗A2血清在10个白血病细胞上进行吸收，但没有足够的血清对健康淋巴细胞进行类似的吸收。这些结果出现了两点。（1）当细胞携带与血清特异性相对应的抗原时，白血病细胞吸收抗HLA抗体的效果与健康淋巴细胞相同。白血病细胞获得的曲线与健康细胞的曲线相当。（2）当细胞不是与抗体特异性相对应的抗原的载体时，白血病细胞也能够吸收抗体，这与没有吸收或吸收不良的健康淋巴细胞不同。
