抗爱泼斯坦-巴尔病毒膜抗原单克隆抗体的制备与鉴定
Production and characterization of monoclonal antibodies against the Epstein-Barr virus membrane antigen.
作者信息
Strnad B C, Schuster T, Klein R, Hopkins R F, Witmer T, Neubauer R H, Rabin H
出版信息
J Virol. 1982 Jan;41(1):258-64. doi: 10.1128/JVI.41.1.258-264.1982.
Five murine hybridoma lines that produce monoclonal antibodies against Epstein-Barr virus membrane antigen (MA) were established. Immunoprecipitation experiments demonstrated that three of the antibodies precipitated both the 236,000 (236K) MA and the 212K MA. The other two antibodies precipitated the 86K MA. Antibodies against the 236K-212K MA and the 86K MA mediated complement-dependent cytolysis of Epstein-Barr-virus-infected cells. The antibodies against the 86K MA neutralized both the B95-8 and P3HR-1 viruses.
建立了五种产生抗爱泼斯坦-巴尔病毒膜抗原（MA）单克隆抗体的小鼠杂交瘤细胞系。免疫沉淀实验表明，其中三种抗体沉淀了236,000（236K）MA和212K MA。另外两种抗体沉淀了86K MA。针对236K - 212K MA和86K MA的抗体介导了爱泼斯坦-巴尔病毒感染细胞的补体依赖性细胞溶解。针对86K MA的抗体中和了B95 - 8和P3HR - 1病毒。
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