Devash Y, Biggs S, Sela I
Science. 1982 Jun 25;216(4553):1415-6. doi: 10.1126/science.6178155.
The oligonucleotide (2'-5') oligoadenylate that is induced in interferon-treated animal cells protects plant tissue from infection by the tobacco mosaic virus. This inhibition of virus multiplication was obtained at concentrations comparable to those affecting protein synthesis and antiviral activities in animal cells. After treatment with (2'-5') oligoadenylate, the multiplicability of tobacco mosaic virus was reduced by 80 to 90 percent as measured by enzyme-linked immunosorbent assay. These results, along with the observation that human interferon protects tobacco tissue from infection by tobacco mosaic virus, indicate that plants and animals may have a common pathway for virus resistance.
在经干扰素处理的动物细胞中诱导产生的寡核苷酸（2'-5'）寡腺苷酸可保护植物组织免受烟草花叶病毒的感染。在与影响动物细胞中蛋白质合成和抗病毒活性的浓度相当的情况下，可实现对病毒繁殖的这种抑制。用（2'-5'）寡腺苷酸处理后，通过酶联免疫吸附测定法测得烟草花叶病毒的增殖能力降低了80%至90%。这些结果，连同人类干扰素可保护烟草组织免受烟草花叶病毒感染这一观察结果，表明植物和动物可能具有共同的抗病毒途径。
