Shvartsman Ia S, Ispolatova A V, Tsybul'skaia N V, Shapiro N I, Aksenov O A
Vopr Virusol. 1982 Mar-Apr;27(2):142-6.
A combined preparation for influenza prevention (CPIP) consisting of an interferon inducer stimulating immunogenesis and killed influenza vaccine is proposed. Twenty five inducers-stimulators have been tested: polynucleotides, polysaccharide and lipopolysaccharide extracted from Salmonella typhosa. Intranasal administration of CPIP to laboratory animals markedly stimulates interferon, secretory, and circulating antibody synthesis. Resistance to fatal influenza infection develops within 18 hours after administration of CPIP and its intensity increases in the following 14 days (the observation period.
提出了一种由刺激免疫发生的干扰素诱导剂和灭活流感疫苗组成的流感预防联合制剂（CPIP）。已经测试了25种诱导-刺激剂：从伤寒沙门氏菌中提取的多核苷酸、多糖和脂多糖。对实验动物进行CPIP鼻内给药可显著刺激干扰素、分泌性抗体和循环抗体的合成。在给予CPIP后18小时内产生对致命性流感感染的抵抗力，并且在接下来的14天（观察期）内其强度增加。
