Yeh H L, Breithardt G, Seipel L, Borggrefe M, Loogen F
Z Kardiol. 1982 Apr;71(4):263-70.
92 patients (mean age 54 +/- 14.7 years, 54 men) with unexplained syncopes were investigated by Holter monitoring, exercise testing and His-bundle-electrography (high-rate and programmed atrial stimulation). The diagnoses on 43 patients were sinus node dysfunction, in 32 cases atrio and/or intraventricular block, and in 6 patients idiopathic atrial fibrillation, whereas 8 patients had a history of ventricular tachycardia, 48 patients received a pacemaker (mean age 58 +/- 12.9 years), and 44 patients were discharged without a pacemaker (mean age 49 +2- 15.6 years). The mean duration of follow-up was 56 +2- 17.1 months. There were 13 deaths, 9 patients died from heart failure, 1 died suddenly, and 3 patients died from non-cardiac causes. 7 patients were lost to follow-up. 54 patients had no syncope any longer, while in 18 cases syncope was still present, 14 patients without pacemaker and 4 patients with pacemaker still had attacks. The cardiac mortality was 18.8% (with pacemaker) and 2.3% (without pacemaker). The only sudden cardiac death was observed in a patient with pacemaker. This study shows that pacemaker implantation bases on electrophysiologic study is able to improve symptoms in patients with syncope. However, the long-term prognosis of the patients is mainly depending on the severity of their underlying heart disease.
对92例不明原因晕厥患者(平均年龄54±14.7岁,54例男性)进行了动态心电图监测、运动试验和希氏束电图检查(高频率和程控心房刺激)。43例患者诊断为窦房结功能障碍,32例为房内和/或室内传导阻滞,6例为特发性心房颤动,8例有室性心动过速病史,48例患者植入了起搏器(平均年龄58±12.9岁),44例患者未植入起搏器出院(平均年龄49±15.6岁)。平均随访时间为56±17.1个月。有13例死亡,9例死于心力衰竭,1例猝死,3例死于非心脏原因。7例失访。54例患者不再发生晕厥,18例仍有晕厥,其中14例未植入起搏器患者和4例植入起搏器患者仍有发作。植入起搏器患者的心脏死亡率为18.8%,未植入起搏器患者为2.3%。唯一的心脏性猝死发生在1例植入起搏器的患者中。本研究表明,基于电生理研究的起搏器植入能够改善晕厥患者的症状。然而,患者的长期预后主要取决于其基础心脏病的严重程度。