Ershov F I, Moshchik K V, Grigorian S S, Fomina A N
Antibiotiki. 1982 Apr;27(4):280-4.
The results of study on 2 Soviet interferon inductors, i.e. the synthetic polyguacyl polynucleotide and natural double-strand phage RNA or dsRNA were studied. It was shown that the time course of accumulation and period of circulation of interferon depended on the route of the inductor administration. The antiviral activity of polyguacyl and dsRNA in experimental influenza and tick-borne encephalitis is described. The maximum protective effect with respect to experimental influenza was observed with intranasal administration of the drugs 4 hours before inoculation. A pronounced protective effect with respect to tick-borne encephalitis was observed with intraperitoneal administration of the inductors or their use in the form of aerosols. Direct correlation between interferon production and the final protective effect was found.
对两种苏联干扰素诱导剂，即合成聚鸟苷酸多核苷酸和天然双链噬菌体RNA或dsRNA的研究结果进行了探讨。结果表明，干扰素的积累时间进程和循环周期取决于诱导剂的给药途径。描述了聚鸟苷酸和dsRNA在实验性流感和蜱传脑炎中的抗病毒活性。在接种前4小时经鼻给药时，对实验性流感观察到最大的保护作用。当诱导剂腹腔给药或以气雾剂形式使用时，对蜱传脑炎观察到显著的保护作用。发现干扰素产生与最终保护作用之间存在直接相关性。
