[Possibilities of overcoming hyporeactivity to interferon induction].

The possibilities of overcoming hyporeactivity to interferon production in mice were studied. Hyporeactivity developing in response to the first inoculation of the inducer was shown not to be overcome by changes of the inoculation sites of the same inducer. Choice of the inducer pairs is of primary importance in overcoming the refractoriness. The maximum effect was found with combination of intraperitoneal injections of Tash-3 followed in 3 days by polyguacyl.