糖尿病状态下3-羟基-3-甲基戊二酸的尿排泄情况。

Urinary excretion of 3-hydroxy-3-methylglutaric acid in the diabetic condition.

作者信息

Deana R, Lippe G, Galzigna L

出版信息

Clin Biochem. 1982 Apr;15(2):73-5. doi: 10.1016/s0009-9120(82)90832-3.

DOI:10.1016/s0009-9120(82)90832-3

Abstract

Urinary levels of 3-hydroxy-3-methylglutaric acid (HMG) were measured by gas-liquid chromatography (GLC) after an extraction with tetrahydrofuran in normal rats, streptozotocin-diabetic rats and starved rats. The analysis was also carried out in the urine of three diabetic patients after suspending the insulin treatment. Detectable amounts of HMG are excreted in urine by normal humans and rats and such an excretion increases in the diabetic condition. Starved rats present only traces of HMG in the urine.

摘要

采用气液色谱法（GLC），通过四氢呋喃萃取，测定正常大鼠、链脲佐菌素诱导的糖尿病大鼠和饥饿大鼠尿液中3-羟基-3-甲基戊二酸（HMG）的含量。在三名糖尿病患者停止胰岛素治疗后的尿液中也进行了该分析。正常人和大鼠的尿液中可检测到一定量的HMG，在糖尿病状态下这种排泄量会增加。饥饿大鼠的尿液中仅存在微量的HMG。

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