在卡介苗致敏小鼠中，牛分枝杆菌卡介苗细胞壁组分在γ干扰素低反应状态下诱导α和β干扰素。
Induction of alpha and beta interferons during the hyporeactive state of gamma interferon by Mycobacterium bovis BCG cell wall fraction in Mycobacterium bovis BCG-sensitized mice.
作者信息
Nakane A, Minagawa T
出版信息
Infect Immun. 1982 Jun;36(3):966-70. doi: 10.1128/iai.36.3.966-970.1982.
Abstract
Characterization of interferon (IFN) induced by a second challenge with specific antigen was investigated during the development of hyporeactivity established after challenge of Mycobacterium bovis BCG-sensitized mice with BCG cell wall fraction (BCG-CW). When BCG-sensitized mice were challenged with BCG-CW, IFN-gamma was detected in the circulation 4 h later and rapidly disappeared. After IFN-gamma disappeared from their blood, mice became completely hyporeactive to the second challenge with BCG-CW for 1 day, and thereafter they recovered from this hyporeactive state. However, we always observed that IFN induced at first by the second challenge with BCG-CW during the hyporeactive state was type I IFN-alpha/beta, but thereafter was entirely IFN-gamma. Induction of IFN-alpha/beta by the specific antigen during restoration from the hyporeactive state in BCG-sensitized mice is discussed.
摘要
在卡介苗（BCG）致敏小鼠用卡介苗细胞壁成分（BCG-CW）攻击后建立低反应性的过程中，研究了第二次用特异性抗原攻击诱导的干扰素（IFN）的特征。当BCG致敏小鼠用BCG-CW攻击时，4小时后在循环中检测到IFN-γ，且其迅速消失。当IFN-γ从血液中消失后，小鼠对第二次BCG-CW攻击完全低反应1天，此后它们从这种低反应状态恢复。然而，我们始终观察到，在低反应状态下最初由第二次BCG-CW攻击诱导的IFN是I型IFN-α/β，但此后完全是IFN-γ。本文讨论了在BCG致敏小鼠从低反应状态恢复过程中特异性抗原对IFN-α/β的诱导作用。
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Hyporeactivity due to infection: recognition of a transferable hyporeactive factor in the serum of encephalomyocarditis virus-infected mice.感染引起的反应性降低：在脑心肌炎病毒感染小鼠血清中识别一种可转移的低反应性因子。
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Immunology. 1979 Apr;36(4):883-90.
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