Johnson C A, Bennett M, Jensen R K, Schirmer R
J Am Vet Med Assoc. 1982 Jun 1;180(11):1330-3.
Bitches with naturally occurring Brucella canis infection were treated with combined antibiotic therapy consisting of tetracycline, dihydrostreptomycin, and trimethoprim-sulfadiazine. After treatment, all but 1 bitch became abacteremic, and serologic titers declined for a variable length of time (3 months to 1 years). Abortion did not occur while these bitches were abacteremic. Although sequential antibiotic therapy for 6 weeks did not eradicate Brucella canis from affected bitches, it did not prevent abortion. The number of live pups whelped and weaned by treated bitches was comparable with that in bitches before they became infected.
患有自然发生的犬布鲁氏菌感染的母犬接受了由四环素、双氢链霉素和甲氧苄啶-磺胺嘧啶组成的联合抗生素治疗。治疗后，除1只母犬外，所有母犬均变为无细菌血症状态，血清学滴度在不同时间段（3个月至1年）下降。这些母犬处于无细菌血症状态时未发生流产。虽然连续6周的抗生素治疗未能从受感染母犬体内根除犬布鲁氏菌，但也并未预防流产。接受治疗的母犬产下并断奶的存活幼犬数量与感染前母犬的数量相当。
