Krishnakumari M K, Muralidhara S, Majumder S K
J Environ Sci Health B. 1982;17(3):241-52. doi: 10.1080/03601238209372316.
Intragastric administration of acute doses of Technical X-factor (beta-isomer free BHC, a byproduct obtained during separation of Lindane from Tech. BHC) carried in peanut oil elicited typical signs of central nervous system depression in adult rats. The computed oral LD50 values of X-factor were 4174 and 5673 mg/kg. body weight for male and female rats respectively indicating that its acute toxicity was of relatively low order compared to Tech. BHC. It is suggested that the low acute mammalian toxicity of X-factor could possibly be due to a direct antagonism of the delta isomer (present in larger proportion in X-factor) with the gamma isomer.
成年大鼠经口给予花生油中携带的急性剂量的工业用X因子（无β异构体的六六六，是从工业用六六六中分离林丹时获得的副产物）会引发典型的中枢神经系统抑制症状。X因子经计算的经口半数致死剂量值，雄性大鼠为4174mg/kg体重，雌性大鼠为5673mg/kg体重，这表明与工业用六六六相比，其急性毒性相对较低。有人提出，X因子的低急性哺乳动物毒性可能是由于δ异构体（在X因子中占比更大）与γ异构体直接拮抗所致。
