Huestis D W
Prog Clin Biol Res. 1982;88:101-14.
Various reactions occur during cytapheresis by either intermittent or continuous flow centrifugation, because of the nature of the procedures themselves and because of the exposure of the donor to steroids, macromolecular agents, anticoagulants, and saline. Most reactions are vasovagal (commoner in intermittent flow procedures) and citrate-related (commoner in continuous flow). Only very rarely do these require the procedure to be stopped. Other less common reactions are discussed. In addition to actual reactions, blood component depletion may occur, especially with frequently repeated procedures in the same donor. Red cell, platelet, and plasma depletion can all force limitation of the frequency of cytapheresis. While most reactions are of little consequence, they can cause procedural failure or refusal of a donor to permit continuation of cytapheresis, and can interfere with donor recruitment.
无论是采用间歇式还是连续流式离心进行血细胞分离术时，由于操作本身的性质以及供者接触类固醇、大分子制剂、抗凝剂和生理盐水等因素，都会发生各种反应。大多数反应是血管迷走性的（在间歇式操作中更常见）和与枸橼酸盐相关的（在连续流式操作中更常见）。这些反应很少需要停止操作。文中还讨论了其他不太常见的反应。除了实际发生的反应外，还可能出现血液成分耗竭，尤其是在同一供者频繁重复进行操作的情况下。红细胞、血小板和血浆的耗竭都可能导致血细胞分离术频率受限。虽然大多数反应影响不大，但它们可能导致操作失败或供者拒绝继续进行血细胞分离术，并可能干扰供者招募。
