鼠伤寒沙门氏菌中recA基因依赖性SOS功能的表达。

Expression of recA-gene dependent SOS functions in Salmonella typhimurium.

作者信息

Guerrero R, Barbé J

出版信息

Antonie Van Leeuwenhoek. 1982 May;48(2):159-67. doi: 10.1007/BF00405200.

Abstract

Thymine starvation of RecA+ Thy- strains of Salmonella typhimurium does not induce the inhibition of cellular respiration, one of the recA-gene dependent SOS functions. Nevertheless, thymine deprivation is able to produce a normal induction of prophage and thymineless death in these same strains However, when these mutants are treated, in the presence of thymine, with UV-irradiation or bleomycin, they show a normal inhibition of cellular respiration and other SOS functions. Thus, one injurious treatment (thymine deprivation) may trigger prophage induction but not cessation of respiration, whereas another agent (UV-irradiation) may induce both. Together, these results suggest a possible discrimination in the pathways and conditions of expression of various SOS functions.

摘要

鼠伤寒沙门氏菌RecA⁺ Thy⁻菌株的胸腺嘧啶饥饿不会诱导细胞呼吸抑制，细胞呼吸抑制是recA基因依赖性SOS功能之一。然而，胸腺嘧啶剥夺能够在这些相同菌株中正常诱导原噬菌体并导致胸腺嘧啶饥饿死亡。但是，当这些突变体在胸腺嘧啶存在的情况下用紫外线照射或博来霉素处理时，它们会表现出正常的细胞呼吸抑制和其他SOS功能。因此，一种有害处理（胸腺嘧啶剥夺）可能触发原噬菌体诱导，但不会导致呼吸停止，而另一种试剂（紫外线照射）可能同时诱导两者。总之，这些结果表明在各种SOS功能的表达途径和条件中可能存在差异。