鼠伤寒沙门氏菌中的DNA损伤诱导位点。
DNA damage-inducible loci in Salmonella typhimurium.
作者信息
Smith C M, Arany Z, Orrego C, Eisenstadt E
机构信息
Department of Cancer Biology, Harvard University School of Public Health, Boston, Massachusetts 02115.
出版信息
J Bacteriol. 1991 Jun;173(11):3587-90. doi: 10.1128/jb.173.11.3587-3590.1991.
Abstract
lac operon fusions to DNA damage-inducible (din) loci were generated in Salmonella typhimurium LT2. Many of these din fusions were efficiently repressed by cloned Escherichia coli LexA, while others were not; all required RecA for induction. Several din fusions exhibited strong inducibility and will be useful in developing an SOS induction assay in S. typhimurium to detect genotoxins.
摘要
在鼠伤寒沙门氏菌LT2中构建了与DNA损伤诱导型（din）基因座的乳糖操纵子融合体。许多这些din融合体被克隆的大肠杆菌LexA有效抑制，而其他的则不然；所有这些融合体的诱导都需要RecA。几个din融合体表现出很强的诱导性，将有助于开发一种用于检测鼠伤寒沙门氏菌中基因毒素的SOS诱导检测方法。
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