大麻素对正常人血小板中单胺氧化酶活性的影响。

Effect of cannabinoids on the activity of monoamine oxidase in normal human platelets.

作者信息

Mazor M, Dvilansky A, Aharon M, Lazarovitz Z, Nathan I

出版信息

Arch Int Physiol Biochim. 1982 Apr;90(1):15-20. doi: 10.3109/13813458209082649.

DOI:10.3109/13813458209082649

Abstract

Platelet MAO activity was affected by preincubation with cannabinoid derivatives in vitro. The psycho-active derivative delta 1-THC inhibited MAO activity in platelets to an extent varying according to its concentration while CBD and (+) delta 6-THC had no inhibitory effect. (-) delta 6-THC, which is minor psychomimetic component, had less inhibitory effect on MAO activity than delta 1-THC. However, (-) DMH delta 6-THC revealed no attenuation effect on MAO inspite of its well-known psychomimetic activity.

摘要

血小板单胺氧化酶（MAO）活性在体外受到与大麻素衍生物预孵育的影响。具有精神活性的衍生物δ1-四氢大麻酚（delta 1-THC）在一定程度上抑制血小板中的MAO活性，其抑制程度随浓度而变化，而大麻二酚（CBD）和（+）δ6-四氢大麻酚（delta 6-THC）则无抑制作用。（-）δ6-四氢大麻酚（delta 6-THC）是一种轻微的拟精神病成分，对MAO活性的抑制作用比对δ1-四氢大麻酚（delta 1-THC）小。然而，（-）二甲基己基四氢大麻酚（-）DMH delta 6-THC尽管具有众所周知的拟精神病活性，但对MAO没有减弱作用。