干扰素在人成纤维细胞中的作用：在未检测到蛋白激酶活性的情况下诱导2',5'-寡腺苷酸合成酶。
Interferon action in human fibroblasts: induction of 2', 5'-oligoadenylate synthetase in the absence of detectable protein kinase activity.
作者信息
Holmes S L, Gupta S L
出版信息
Arch Virol. 1982;72(1-2):137-42. doi: 10.1007/BF01314459.
PMID:6179503
Abstract
In several strains of human fibroblasts, treatment with human alpha- or beta-interferon (IFN) resulted in an induction of 2', 5'-oligoadenylate synthetase but no protein kinase activity. The antiviral and anticellular effects of IFN are elicited in these cells in the absence of detectable IFN-induced protein kinase activity.
摘要
在几种人成纤维细胞系中，用人α-或β-干扰素（IFN）处理会诱导2'，5'-寡腺苷酸合成酶的产生，但不会诱导蛋白激酶活性。在这些细胞中，即使没有可检测到的IFN诱导的蛋白激酶活性，IFN的抗病毒和抗细胞作用也会被引发。
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