Palliative treatment of tardive dyskinesia with combination of amantadine-neuroleptic administration.

The author presents six cases which suggest a palliative effect of combination amantadine/neuroleptic in tardive dyskinesia. The six patients all met criteria for definite tardive dyskinesia, and did not have coexistent pseudoparkinsonism. Serial addition and subtraction of amantadine with fixed low-dose neuroleptic points to a specific amantadine effect. Previous studies are reviewed and speculation about the mechanism of action of the combination is discussed.