Myslobodsky M, Mintz M, Ben-Mayor V, Radwan H
Electroencephalogr Clin Neurophysiol. 1982 Aug;54(2):227-31. doi: 10.1016/0013-4694(82)90164-x.
The hypothesis was tested that unilateral dopamine deficiency leading to the contralateral extrapyramidal syndrome (hemi-parkinsonism) would cause distinctly asymmetric EEG sleep patterns. In 7 hemi-Parkinson's patients 2 nights of sleep were monitored along with pre-sleep waking periods. No medication was given prior to the first night. The second night followed at least 2 months of L-DOPA medication. Although in all patients sleep architecture was disturbed, no statistically significant asymmetries of sleep patterns were obtained. L-DOPA medication improved the quality of sleep. Delta sleep was most visibly improved. Also, post-treatment enhancement of the mean delta power over the parkinsonian hemisphere was supported statistically. The role of dopamine in slow wave sleep control and mechanisms of contralateral hemisphere involvement are discussed.
单侧多巴胺缺乏导致对侧锥体外系综合征（偏侧帕金森症）会引起明显不对称的脑电图睡眠模式。对7例偏侧帕金森症患者的睡眠进行了2个晚上的监测，并同时监测了睡前清醒期。第一个晚上未给予任何药物治疗。第二个晚上是在至少2个月的左旋多巴药物治疗之后进行的。尽管所有患者的睡眠结构均受到干扰，但未获得睡眠模式在统计学上的显著不对称性。左旋多巴药物治疗改善了睡眠质量。慢波睡眠改善最为明显。此外，治疗后帕金森症侧半球平均慢波功率增强也得到了统计学支持。文中讨论了多巴胺在慢波睡眠控制中的作用以及对侧半球受累的机制。
