Takahashi T, Goto K, Sudo S, Suzuki M
Endocrinol Jpn. 1981 Dec;28(6):799-808. doi: 10.1507/endocrj1954.28.799.
The tubulin content and biochemical components were determined in the cerebrum, cerebellum and hypothalamus from intact and T3-treated male and female rats during early life. T3-treatment between 0 and 9 days of age increased soluble protein, RNA DNA and tubulin content (mg per g tissue) in the 10-day-old male cerebellum but not in the cerebrum and hypothalamus except for soluble protein and tubulin (mg per g tissue), respectively. Intracellular tubulin content (mg per mg DNA) was increased by the T3-treatment in the 10-day-old male hypothalamus but not the other regions. When T3 was administered between 10 and 19 days, there was little effect of the treatment; increased tubulin (mg per g tissue) in the cerebrum and decreased RNA (mg per g tissue) and a ratio of tubulin to protein in the cerebellum from 20-day-old males. Less response to T3-treatment was observed in female cerebrum and hypothalamus but not in the cerebellum, compared with the male. These results suggest that the effect of T3-treatment on brain is modified by several factors such as tissue specificity, age-dependency and sexual differences. Modification by these factors might depend, at least in part, on changes in the number of T3-receptors due to the hormone treatment.
在生命早期，对完整的以及经三碘甲状腺原氨酸（T3）处理的雄性和雌性大鼠的大脑、小脑和下丘脑的微管蛋白含量及生化成分进行了测定。在0至9日龄期间接受T3处理，会使10日龄雄性大鼠小脑中的可溶性蛋白、RNA、DNA和微管蛋白含量（每克组织毫克数）增加，但在大脑和下丘脑，除了可溶性蛋白和微管蛋白（每克组织毫克数）分别增加外，其他成分并无变化。在10日龄雄性大鼠的下丘脑中，T3处理使细胞内微管蛋白含量（每毫克DNA毫克数）增加，而其他区域则无此现象。当在10至19日龄期间给予T3时，处理效果甚微；20日龄雄性大鼠大脑中的微管蛋白（每克组织毫克数）增加，小脑中的RNA（每克组织毫克数）减少，且微管蛋白与蛋白质的比例降低。与雄性相比，雌性大鼠的大脑和下丘脑对T3处理的反应较小，而小脑则不然。这些结果表明，T3处理对大脑的影响会受到多种因素的调节，如组织特异性、年龄依赖性和性别差异。这些因素的调节作用可能至少部分取决于激素处理导致的T3受体数量变化。
