Chaudhury S, Chatterjee D, Sarkar P K
Brain Res. 1985 Jul 22;339(1):191-4. doi: 10.1016/0006-8993(85)90644-4.
The relative effects of triiodothyronine (T3) on the synthesis and turnover of tubulin in the developing rat and chick brain have been examined. Measurements of rates of turnover of radiolabeled tubulin in the hormone-sensitive tissues show that the half-life of tubulin turnover is 4-6 h in the absence of T3 and 10-12 h in the presence of the hormone. Analysis of short-term kinetic data on the stimulation of tubulin by T3 in the chick brain show that the rapid induction is due to a dual effect of the hormone on the metabolism of tubulin--an increase in the rate of synthesis as well as a decline in its rate of turnover.
已研究了三碘甲状腺原氨酸（T3）对发育中的大鼠和鸡大脑微管蛋白合成与周转的相对影响。对激素敏感组织中放射性标记微管蛋白周转速率的测量表明，在没有T3的情况下，微管蛋白周转的半衰期为4 - 6小时，而在有该激素的情况下为10 - 12小时。对鸡大脑中T3刺激微管蛋白的短期动力学数据的分析表明，快速诱导是由于该激素对微管蛋白代谢的双重作用——合成速率增加以及周转速率下降。
