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Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1.

作者信息

Lasky S R, Jacobs B L, Samuel C E

出版信息

J Biol Chem. 1982 Sep 25;257(18):11087-93.

PMID:6179946
Abstract
摘要

相似文献

1
Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1.干扰素作用机制。小鼠成纤维细胞中干扰素诱导的磷蛋白P1磷酸化位点的特性：P1两种形式的证据。
J Biol Chem. 1982 Sep 25;257(18):11087-93.
2
Mechanism of interferon action. Production and characterization of monoclonal and polyclonal antibodies to the interferon-induced phosphoprotein P1.
Biochem Biophys Res Commun. 1985 Nov 27;133(1):168-75. doi: 10.1016/0006-291x(85)91856-x.
3
Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts.干扰素作用机制。未处理及经干扰素处理的小鼠成纤维细胞中双链RNA依赖性蛋白激酶的纯化及底物特异性
J Biol Chem. 1985 Sep 15;260(20):11240-7.
4
Molecular mechanisms of interferon action: interferon-mediated phosphorylation of ribosome-associated protein P1 and protein synthesis initiation factor eIF-2.干扰素作用的分子机制：干扰素介导的核糖体相关蛋白P1和蛋白质合成起始因子eIF-2的磷酸化
Tex Rep Biol Med. 1981;41:463-70.
5
Mechanism of interferon action. The interferon-induced phosphoprotein P1 possesses a double-stranded RNA-dependent ATP-binding site.干扰素作用机制。干扰素诱导的磷蛋白P1具有一个双链RNA依赖性ATP结合位点。
J Biol Chem. 1985 Jul 15;260(14):8237-9.
6
Mechanism of interferon action. Kinetics of induction of the antiviral state and protein phosphorylation in mouse fibroblasts treated with natural and cloned interferons.干扰素作用机制。天然干扰素和克隆干扰素处理的小鼠成纤维细胞中抗病毒状态诱导及蛋白质磷酸化的动力学。
J Biol Chem. 1982 Oct 10;257(19):11791-5.
7
Specific phosphorylation in vitro of a protein associated with ribosomes of interferon-treated mouse L cells.与经干扰素处理的小鼠L细胞核糖体相关的一种蛋白质的体外特异性磷酸化作用。
FEBS Lett. 1976 Sep 15;68(1):119-24. doi: 10.1016/0014-5793(76)80418-8.
8
Double-stranded RNA inhibits a phosphoprotein phosphatase present in interferon-treated cells.双链RNA抑制存在于经干扰素处理的细胞中的一种磷蛋白磷酸酶。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):107-11. doi: 10.1073/pnas.77.1.107.
9
Mechanism of interferon action. Effect of double-stranded RNA and the 5'-O-monophosphate form of 2',5'-oligoadenylate on the inhibition of reovirus mRNA translation in vitro.干扰素作用机制。双链RNA和2',5'-寡腺苷酸的5'-O-单磷酸形式对呼肠孤病毒mRNA体外翻译抑制作用的影响。
J Biol Chem. 1983 Dec 25;258(24):15232-7.
10
Double-stranded RNA-dependent phosphorylation of protein P1 and eukaryotic initiation factor 2 alpha does not correlate with protein synthesis inhibition in a cell-free system from interferon-treated mouse L cells.在经干扰素处理的小鼠L细胞的无细胞体系中，蛋白质P1和真核起始因子2α的双链RNA依赖性磷酸化与蛋白质合成抑制不相关。
Proc Natl Acad Sci U S A. 1983 Jan;80(1):41-5. doi: 10.1073/pnas.80.1.41.

引用本文的文献

1
Auto-phosphorylation Represses Protein Kinase R Activity.自身磷酸化抑制蛋白激酶 R 的活性。
Sci Rep. 2017 Mar 10;7:44340. doi: 10.1038/srep44340.
2
A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase.一种常用于抑制蛋白激酶R（PKR）的化合物，{8-（咪唑-4-基亚甲基）-6H-氮杂环丁烷并[5,4-g]苯并噻唑-7-酮}，通过抑制细胞周期蛋白依赖性激酶来保护神经元。
Eur J Neurosci. 2008 Nov;28(10):2003-16. doi: 10.1111/j.1460-9568.2008.06491.x.
3
Antiviral actions of interferons.
干扰素的抗病毒作用。
Clin Microbiol Rev. 2001 Oct;14(4):778-809, table of contents. doi: 10.1128/CMR.14.4.778-809.2001.
4
Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.丙型肝炎病毒包膜蛋白E2并非通过与RNA结合结构域中的自磷酸化位点简单竞争来抑制PKR。
J Virol. 2001 Feb;75(3):1265-73. doi: 10.1128/JVI.75.3.1265-1273.2001.
5
Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.自磷酸化位点参与双链RNA激活蛋白激酶PKR的激活过程。
Mol Cell Biol. 1996 Nov;16(11):6295-302. doi: 10.1128/MCB.16.11.6295.
6
Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.干扰素作用机制：干扰素诱导的双链RNA特异性腺苷脱氨酶中功能不同的RNA结合结构域和催化结构域。
J Virol. 1996 Mar;70(3):1961-8. doi: 10.1128/JVI.70.3.1961-1968.1996.
7
In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.人α-原肌球蛋白3'非翻译区的RNA在体外激活干扰素诱导的双链RNA依赖性蛋白激酶PKR
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):508-13. doi: 10.1073/pnas.93.1.508.
8
Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vivo in the absence of its dsRNA binding domain.
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10551-5. doi: 10.1073/pnas.91.22.10551.
9
Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.干扰素作用机制：干扰素诱导的RNA依赖性蛋白激酶PKR分子间自磷酸化和自激活的证据
J Virol. 1993 Dec;67(12):7695-700. doi: 10.1128/JVI.67.12.7695-7700.1993.
10
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.双链RNA依赖的蛋白激酶与反式激活应答元件RNA结合蛋白在体内形成同二聚体和异二聚体。
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9445-9. doi: 10.1073/pnas.92.21.9445.