肝脏在人α-和β-干扰素分解代谢中的作用。

The role of liver in the catabolism of human alpha- and beta-interferon.

作者信息

Bocci V, Pacini A, Bandinelli L, Pessina G P, Muscettola M, Paulesu L

出版信息

J Gen Virol. 1982 Jun;60(Pt 2):397-400. doi: 10.1099/0022-1317-60-2-397.

Abstract

The susceptibility of human leukocyte (alpha), fibroblast (beta) and recombinant alpha-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant alpha-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that alpha-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human beta-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.

摘要

已评估人白细胞（α）干扰素、成纤维细胞（β）干扰素及重组α-2干扰素在兔离体灌注肝脏中的清除率。人白细胞干扰素和重组α-2干扰素性质稳定，即便经过神经氨酸酶处理，其在灌注液中的初始水平仍能维持，这表明α干扰素没有可被肝脏结合蛋白识别的外露糖基。另一方面，天然的，尤其是去唾液酸化的人β干扰素会被肝脏显著摄取，这证实了肝脏作为糖基化干扰素分解代谢场所的重要性。