唾液酸在决定循环干扰素存活中的作用。
The role of sialic acid in determining the survival of circulating interferon.
作者信息
Bocci V, Pacini A, Pessina G P, Bargigli V, Russi M
出版信息
Experientia. 1977 Feb 15;33(2):164-6. doi: 10.1007/BF02124043.
PMID:844537
Abstract
Rabbit interferon has been extensively desialytated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catobolic pathway for this glycoprotein.
摘要
兔干扰素已被广泛地脱唾液酸，并在兔体内评估了其代谢行为。去唾液酸干扰素的半衰期明显短于天然干扰素，其尿排泄量可忽略不计。此外，分离并灌注的兔肝脏对去唾液酸干扰素的快速摄取，提示了这种糖蛋白迄今未被怀疑的分解代谢途径。
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