Pomarede R, Czernichow P, Finidori J, Pfister A, Roger M, Kalifa C, Zucker J M, Pierre-Kahn A, Rappaport R
J Pediatr. 1982 Sep;101(3):374-8. doi: 10.1016/s0022-3476(82)80060-7.
This work outlines the endocrine abnormalities associated with intracranial germinomas (14 patients before treatment). Diabetes insipidus of various intensity was present in all cases. Adipsia is often present as well. In six patients, the first neuroradiologic examination after the onset of DI was normal. Growth hormone secretion was deficient in 11 of 13 patients. Abnormalities of TSH response to TRH were present in nine of ten (four insufficient and five exaggerated responses to TRH). Anterior pituitary dysfunction could not be predicted by the tumor site as determined by radiologic criteria. Tumoral markers have also been studied. Elevated plasma tumoral markers were found in four patients of 11 studied. Tumoral germinoma cells were present in CSF in five patients of ten, in one of them before radiologic confirmation. Pertinent endocrine evaluation and search for tumoral markers was of great value in systematic follow-up of patients with central diabetes insipidus, and could lead to early diagnosis and treatment of the tumor.
这项研究概述了与颅内生殖细胞瘤相关的内分泌异常情况（14例治疗前患者）。所有病例均存在不同程度的尿崩症。常伴有渴感缺失。6例患者在尿崩症发作后的首次神经放射学检查结果正常。13例患者中有11例生长激素分泌不足。10例患者中有9例促甲状腺激素对促甲状腺激素释放激素的反应异常（4例反应不足，5例反应过度）。根据放射学标准确定的肿瘤部位无法预测垂体前叶功能障碍。还对肿瘤标志物进行了研究。在11例接受研究的患者中，有4例血浆肿瘤标志物升高。10例患者中有5例脑脊液中存在肿瘤生殖细胞瘤细胞，其中1例在放射学确诊前就已发现。相关的内分泌评估和肿瘤标志物检测对于中枢性尿崩症患者的系统随访具有重要价值，可导致肿瘤的早期诊断和治疗。
