Ziche M, Gullino P M
J Natl Cancer Inst. 1982 Aug;69(2):483-7.
In vivo cell populations at high risk of neoplastic transformation have been shown to acquire the ability to induce new formation of vessels. The present experiments tested whether the same change occurred during neoplastic transformation in vitro. In four cell populations (human HBL 100 mammary epithelium, BALB/c fibroblasts, C57BL-MG epithelium, and Syrian golden hamster embryo cells), angiogenic capacity appeared during their cultivation in vitro and was evident long before a neoplastic transformation could be recognized. The data were interpreted to support the hypothesis that acquisition of angiogenic capacity by a cell population normally devoid of this capacity indicates an increased risk of neoplastic transformation.
体内具有高肿瘤转化风险的细胞群体已被证明能够获得诱导新血管形成的能力。本实验测试了在体外肿瘤转化过程中是否发生了同样的变化。在四个细胞群体（人HBL 100乳腺上皮细胞、BALB/c成纤维细胞、C57BL - MG上皮细胞和叙利亚金黄地鼠胚胎细胞）中，血管生成能力在体外培养过程中出现，并且早在能够识别肿瘤转化之前就很明显了。这些数据被解释为支持这样一种假设，即通常不具备这种能力的细胞群体获得血管生成能力表明肿瘤转化风险增加。
