Muthukkaruppan V R, Kubai L, Auerbach R
J Natl Cancer Inst. 1982 Sep;69(3):699-708.
Tumor fragments implanted in the mouse cornea induce a neovascular reaction characterized by the penetration of new blood vessels into the avascular cornea that ultimately reach the tumor to permit its further rapid growth. A method to achieve angiogenesis in the mouse cornea was studied, as well as the histologic and gross manifestations of the neovascular reaction and the effect of tumor cells or host irradiation on the observed angiogenic response. Sequential stages of tumor-induced neovascularization are described and documented for sarcoma 180- and C755 mammary adenocarcinoma-induced angiogenesis. A number of distinct processes of the angiogenesis response to tumors are discussed which suggest that several families of angiogenesis-inducing factors may mediate each of these processes. The importance of the development of a mouse model for the study of angiogenesis is stressed.
植入小鼠角膜的肿瘤碎片会引发一种新生血管反应，其特征是新血管穿透无血管的角膜，最终抵达肿瘤，使其得以进一步快速生长。研究了一种在小鼠角膜中实现血管生成的方法，以及新生血管反应的组织学和大体表现，还有肿瘤细胞或宿主辐射对所观察到的血管生成反应的影响。描述并记录了肉瘤180和C755乳腺腺癌诱导血管生成过程中肿瘤诱导新生血管形成的连续阶段。讨论了对肿瘤血管生成反应的一些不同过程，这表明几个血管生成诱导因子家族可能介导这些过程中的每一个。强调了开发用于研究血管生成的小鼠模型的重要性。
