Eiján A M, Davel L, de Lustig E S
Departamento de Investigaciones, Instituto de Oncología, Angel H. Roffo, Universidad de Buenos Aires, Capital Federal, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1993;43(3-4):53-7.
The neovascularization is a known event in the de development of tumors. The progressive growth of solid tumors is strictly dependent on angiogenesis. Furthermore, shedding of tumor cells into the circulation is not observed in a prevascular phase of tumors. Therefore, the inhibition of angiogenesis could be a good target for cancer control. Lymphocytes from, tumor bearing-mice were capable of inducing neovascular response in the skin of syngeneic mice. This response was named syngeneic lymphocyte-induced angiogenesis (SLIA). This work was an attempt to study if two proteins present in extracellular matrix, collagen and fibronectin (FN), could modulate lymphocyte-induced angiogenesis. The angiogenic response induced by lymphocytes from S13 tumor bearing-nice in the skin of BAL/c mice was blocked by treatment with FN and Gly. Arg. Gly. Asp. peptide. On the contrary, collagen and Gly. Arg. Gly. Asp. Ser did not modify SLIA response.
新血管生成是肿瘤发展过程中一个已知的现象。实体瘤的渐进性生长严格依赖于血管生成。此外，在肿瘤的血管前期阶段未观察到肿瘤细胞进入循环。因此，抑制血管生成可能是控制癌症的一个良好靶点。来自荷瘤小鼠的淋巴细胞能够在同基因小鼠的皮肤中诱导新血管反应。这种反应被命名为同基因淋巴细胞诱导的血管生成（SLIA）。这项工作旨在研究细胞外基质中存在的两种蛋白质，胶原蛋白和纤连蛋白（FN），是否能够调节淋巴细胞诱导的血管生成。用FN和甘氨酸-精氨酸-甘氨酸-天冬氨酸肽处理可阻断S13荷瘤小鼠的淋巴细胞在BAL/c小鼠皮肤中诱导的血管生成反应。相反，胶原蛋白和甘氨酸-精氨酸-甘氨酸-天冬氨酸-丝氨酸并未改变SLIA反应。
