McCluskey D R
Med Hypotheses. 1982 Jun;8(6):627-34. doi: 10.1016/0306-9877(82)90045-7.
This paper proposes the hypothesis that cells which express fetal antigen activate a variety of suppressor mechanisms and thus induce a state of immunological tolerance. Clinical and experimental evidence is cited which supports the hypothesis and indicates that foreign antigens, expressed in association with fetal antigen, are actively tolerated. Thus the fetus, which bears foreign histocompatibility antigens and neoplastic tumours which re-express fetal antigens, fail to evoke appropriate immunological rejection responses, but rather induce a state of active tolerance.
本文提出一种假说，即表达胎儿抗原的细胞会激活多种抑制机制，从而诱导免疫耐受状态。文中引用了临床和实验证据来支持这一假说，并表明与胎儿抗原相关表达的外来抗原会被主动耐受。因此，携带外来组织相容性抗原的胎儿以及重新表达胎儿抗原的肿瘤，不会引发适当的免疫排斥反应，反而会诱导出主动耐受状态。
