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幼猴纹状皮层损伤后背外侧膝状核神经元肥大

Hypertrophy of neurons in dorsal lateral geniculate nucleus following striate cortex lesions in infant monkeys.

作者信息

Hendrickson A, Dineen J T

出版信息

Neurosci Lett. 1982 Jun 30;30(3):217-22. doi: 10.1016/0304-3940(82)90402-5.

DOI:10.1016/0304-3940(82)90402-5
PMID:6180362
Abstract

Monkeys whose left striate cortex had been removed in infancy received bilateral injections of horseradish peroxidase (HRP) into the prelunate gyrus (PLG) prestriate cortex. Scattered large neurons in the dorsal lateral geniculate nucleus were retrogradely labeled in both hemispheres. On the lesioned side, the HRP-labeled cell bodies were 58% larger in area, showing an overall increase in soma size and complexity of dendritic field, suggesting a hypertrophy of the geniculate-PLG pathway following a neonatal striate cortex lesion.

摘要

在婴儿期切除左侧纹状皮质的猴子,双侧注射辣根过氧化物酶(HRP)到月状前回(PLG)的纹前皮质。双侧背外侧膝状核中均有散在的大神经元被逆行标记。在损伤侧,HRP标记的细胞体面积大58%,表明胞体大小和树突野复杂性总体增加,提示新生儿纹状皮质损伤后膝状核-PLG通路肥大。

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