Yukie M, Iwai E
J Comp Neurol. 1981 Sep 1;201(1):81-97. doi: 10.1002/cne.902010107.
The enzyme horseradish peroxidase (HRP) was separately injected into striate, prestriate, inferotemporal, and parietal cortices in 19 macaque monkeys, and the lateral geniculate nucleus (LGN) was examined for retrograde transport. Labeled LGN cells were identified only in the animals, with HRP injections into the striate and prestriate cortex. Following injections into either of these regions, labeled cells were found in both parvocellular and magnocellular regions of the ipsilateral LGN only, in keeping with the topographic relation of HRP injection sites in the cortex to labeled areas in the LGN. It was also found that (1) labeled LGN cells were less numerous in both laminar and interlaminar zones following HRP injection into the prestriate cortex, whereas following HRP injection into the striate cortex labeled cells were found almost exclusively in the laminae, and localized to a wedge-shaped region; (2) following HRP injection into the prestriate cortex, the mean sizes of the labeled parvocellular and magnocellular cells, estimated in projected diameter, were almost the same, these means being significantly larger than the mean size of labeled parvocellular cells and much smaller than that of labeled magnocellular cells following HRP injection into the striate cortex; (3) the shapes of the labeled LGN cells following HRP injection into the prestriate cortex were ovoid, fusiform, or triangular (or multipolar), whereas those following HRP injection into the striate cortex were uniformly ovoid or round. The above findings following HRP injections into the prestriate cortex in normal monkeys were confirmed by HRP injections into the prestriate cortex of monkeys whose striate cortex had been removed several months prior to the injection; labeled cells were found in confines of areas of retrograde degeneration in the LGN and their labeling pattern was the same as that in intact animals. It was concluded that in macaque monkeys, just as in the cat, a geniculoprestriate projection system exists; it was suggested that there are two parallel system of visual information processing from the LGN to the prestriate cortex, a direct one and in indirect one through the striate cortex.
将辣根过氧化物酶（HRP）分别注射到19只猕猴的纹状皮层、纹前皮层、颞下皮层和顶叶皮层，并检查外侧膝状体核（LGN）的逆行运输情况。仅在将HRP注射到纹状皮层和纹前皮层的动物中发现了标记的LGN细胞。在向这两个区域中的任何一个区域注射后，仅在同侧LGN的小细胞区和大细胞区发现了标记细胞，这与皮层中HRP注射部位与LGN中标记区域的拓扑关系一致。还发现：（1）将HRP注射到纹前皮层后，LGN的层内和层间区域中标记的细胞数量较少，而将HRP注射到纹状皮层后，标记细胞几乎仅见于各层，并局限于一个楔形区域；（2）将HRP注射到纹前皮层后，根据投影直径估计，标记的小细胞和大细胞的平均大小几乎相同，这些平均值显著大于将HRP注射到纹状皮层后标记的小细胞的平均大小，且远小于标记的大细胞的平均大小；（3）将HRP注射到纹前皮层后，标记的LGN细胞形状为卵圆形、梭形或三角形（或多极），而将HRP注射到纹状皮层后，标记细胞均为卵圆形或圆形。在正常猕猴的纹前皮层注射HRP后的上述发现，通过在注射前几个月已切除纹状皮层的猕猴的纹前皮层注射HRP得到了证实；在LGN逆行变性区域内发现了标记细胞，其标记模式与完整动物相同。得出的结论是，在猕猴中，与猫一样，存在一个膝状体 - 纹前投射系统；有人提出，从LGN到纹前皮层存在两个并行的视觉信息处理系统，一个是直接的，另一个是通过纹状皮层的间接系统。
