促肾上腺皮质激素、苯二氮䓬类药物和5-羟色胺拮抗剂对大鼠中脑导水管周围灰质刺激逃避反应的影响。
Effects of ACTH, benzodiazepines and 5-HT antagonists on escape from periaqueductal grey stimulation in the rat.
作者信息
Clarke A, File S E
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(1):27-35. doi: 10.1016/s0364-7722(82)80104-5.
PMID:6180456
Abstract
- The effects of drugs has been studied on escape behaviour of rats following electrical stimulation of the periaqueductal grey, in order to assess the feasibility of using the latency to escape as a measure of experimental anxiety. 2. Escape latencies were decreased by methysergide and cyproheptadine, whilst lorazepam and chlordiazepoxide (CDP) increased the latencies. 3. ACTH marginally decreased escape latencies, and did not alter the response to lorazepam. 4. Difficulties associated with using this paradigm to detect anxiolytic or anxiogenic effects of drugs are discussed.
摘要
- 为评估将逃避潜伏期用作实验性焦虑指标的可行性，已对药物对大鼠在中脑导水管周围灰质电刺激后逃避行为的影响进行了研究。2. 甲基麦角新碱和赛庚啶可缩短逃避潜伏期，而劳拉西泮和氯氮卓（CDP）则延长潜伏期。3. 促肾上腺皮质激素（ACTH）略微缩短逃避潜伏期，且不改变对劳拉西泮的反应。4. 讨论了使用该范式检测药物抗焦虑或致焦虑作用时存在的困难。
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