Cordier J F, Grimaud J A, Lasne Y, Touraine R
Rev Fr Mal Respir. 1982;10(3):151-74.
Collagen is a macro-molecule of polypeptide chains arranged in a triple helix. The biosynthesis and degradation of collagen require complex enzymes systems; considerable progress has been made in their understanding in recent years. Collagen is the most important connective tissue of the body and five types are present in the lower respiratory tract. Genetic disorders of collagen (e.g. the Ehlers-Danlos or Marfan's syndrome) may affect the lung. Furthermore certain pulmonary diseases such as fibrosis are associated with changes in the ratio of the different types of collagen. Collagen can no longer be dissociated from the study of tissue changes in pulmonary pathology; the aim of our study is to provide elementary data concerning this aspect of modern pneumology.
胶原蛋白是一种以三股螺旋形式排列的多肽链大分子。胶原蛋白的生物合成和降解需要复杂的酶系统；近年来，人们对其的认识取得了相当大的进展。胶原蛋白是人体最重要的结缔组织，下呼吸道中存在五种类型。胶原蛋白的遗传疾病（如埃勒斯-当洛综合征或马凡综合征）可能会影响肺部。此外，某些肺部疾病，如纤维化，与不同类型胶原蛋白比例的变化有关。在肺部病理学中，胶原蛋白与组织变化的研究已无法分割；我们研究的目的是提供有关现代肺病学这一方面的基础数据。
