Lane D A, Ireland H, Wolff S, Grant R, Jennings S, Allen-Mersh T
Thromb Res. 1982 Apr 15;26(2):111-8. doi: 10.1016/0049-3848(82)90020-2.
Plasma concentrations of thrombin sensitive peptide fibrinopeptide A (FpA), plasmin sensitive fibrinogen fragment B beta 1-42 and the platelet release product beta-thromboglobulin (beta TG) have been measured in 36 patients before and after total hip replacement. Statistically significant elevations of all three activation products were observed in the days following operation. There were small differences in plasma concentrations of FpA, B beta 1-42 and beta TG in patients who did (n = 13) and did not (n = 23) develop post operative deep vein thrombosis, as assessed by ascending venography on post operative day 10, but these differences were not statistically significant. It is concluded that coagulation and fibrinolytic systems and also blood platelets are activated following total hip replacement operations. However, the formation of post operative deep vein thrombosis can not be effectively monitored by measurement of the activation products.
对36例患者在全髋关节置换术前和术后测定了凝血酶敏感肽纤维蛋白肽A（FpA）、纤溶酶敏感的纤维蛋白原片段Bβ1 - 42以及血小板释放产物β - 血栓球蛋白（βTG）的血浆浓度。术后数天观察到所有这三种激活产物均有统计学意义的升高。在术后第10天行上行静脉造影评估，发生（n = 13）和未发生（n = 23）术后深静脉血栓形成的患者，其FpA、Bβ1 - 42和βTG的血浆浓度存在微小差异，但这些差异无统计学意义。得出的结论是，全髋关节置换术后凝血和纤溶系统以及血小板均被激活。然而，通过测定激活产物不能有效地监测术后深静脉血栓的形成。
