Johannessen J V, Sobrinho-Simões M
Am J Clin Pathol. 1982 Sep;78(3):299-310. doi: 10.1093/ajcp/78.3.299.
Twenty-five adenomas of the thyroid were studied by transmission and scanning electron microscopy: 14 embryonal, fetal, and simple adenomas, 1 colloid adenoma, 2 toxic adenomas, 2 oxyphil adenomas, 2 "atypical adenomas" and 4 adenomas with capsular invasion, formerly designated "malignant adenomas." The only adenomas that presented with special ultrastructural features were the oxyphil and the toxic varieties. The toxic adenomas had organelle-rich cells with numerous and long microvilli on their surfaces. The oxyphil adenomas showed Hürthle cell changes, including abundant mitochondria, and smooth cell surfaces. The subdivision of the other forms of adenomas was impossible at the ultrastructural level; and this study did not reveal ultrastructural features which could distinguish the so-called "atypical" and "malignant" adenomas from ordinary thyroid adenomas. "Malignant" adenomas should preferable be called what they are: adenomas with capsular invasion. Neither does this study support the view that electron microscopy is a useful method to separate an adenoma from a well-differentiated follicular carcinoma in the occasional patient who presents problems.
通过透射电子显微镜和扫描电子显微镜对25例甲状腺腺瘤进行了研究：14例胚胎型、胎儿型和单纯性腺瘤，1例胶样腺瘤，2例毒性腺瘤，2例嗜酸性细胞腺瘤，2例“非典型腺瘤”以及4例有包膜侵犯的腺瘤，以前称为“恶性腺瘤”。呈现特殊超微结构特征的腺瘤仅有嗜酸性细胞腺瘤和毒性腺瘤。毒性腺瘤有富含细胞器的细胞，其表面有许多长微绒毛。嗜酸性细胞腺瘤呈现许特莱细胞变化，包括丰富的线粒体和平滑的细胞表面。在超微结构水平上无法对其他形式的腺瘤进行细分；并且本研究未揭示能将所谓的“非典型”和“恶性”腺瘤与普通甲状腺腺瘤区分开来的超微结构特征。“恶性”腺瘤最好应按其本质来称呼：有包膜侵犯的腺瘤。本研究也不支持这样一种观点，即对于偶尔出现问题的患者，电子显微镜检查是将腺瘤与高分化滤泡癌区分开来的有用方法。
