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Separation and identification of subpicomole amounts of methotrexate polyglutamates in animal and human biopsy material.

作者信息

Krakower G R, Nylen P A, Kamen B A

出版信息

Anal Biochem. 1982 May 15;122(2):412-6. doi: 10.1016/0003-2697(82)90303-7.

DOI:10.1016/0003-2697(82)90303-7
PMID:6180658
Abstract
摘要

相似文献

1
Separation and identification of subpicomole amounts of methotrexate polyglutamates in animal and human biopsy material.动物和人体活检材料中亚皮摩尔量甲氨蝶呤多聚谷氨酸盐的分离与鉴定。
Anal Biochem. 1982 May 15;122(2):412-6. doi: 10.1016/0003-2697(82)90303-7.
2
Analysis of methotrexate polyglutamate derivatives in vivo.
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4
Separation and identification of methotrexate and its metabolites, 7-hydroxymethotrexate and polyglutamates, in human tissues by reversed-phase high-performance liquid chromatography coupled with radioimmunoassay.采用反相高效液相色谱-放射免疫分析法分离并鉴定人体组织中的甲氨蝶呤及其代谢产物7-羟基甲氨蝶呤和聚谷氨酸盐。
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Folate and methotrexate polyglutamate tissue levels in rhesus monkeys following chronic low-dose methotrexate.慢性低剂量甲氨蝶呤给药后恒河猴体内叶酸和甲氨蝶呤多聚谷氨酸的组织水平
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Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue.采用高效液相色谱法检测接受大剂量甲氨蝶呤/亚叶酸钙解救治疗的骨肉瘤患者肿瘤组织中甲氨蝶呤及其代谢物。
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In situ methotrexate polyglutamate formation in rat tissues.
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Capillary electrophoresis of methotrexate polyglutamates and its application in evaluation of gamma-glutamyl hydrolase activity.甲氨蝶呤多聚谷氨酸的毛细管电泳及其在γ-谷氨酰水解酶活性评估中的应用
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Simultaneous determination of erythrocyte methotrexate polyglutamates by a novel and simple HPLC-MS/MS method with stable isotope-labeled internal standards.采用新型简单的 HPLC-MS/MS 法，以稳定同位素标记的内标物同时测定红细胞中甲氨蝶呤多聚谷氨酸。
J Sep Sci. 2021 May;44(9):1852-1865. doi: 10.1002/jssc.202001081. Epub 2021 Mar 18.
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引用本文的文献

1
Methotrexate metabolism.甲氨蝶呤代谢
Cancer Chemother Pharmacol. 1983;10(3):230-1. doi: 10.1007/BF00255773.
2
Clinical pharmacokinetics of methotrexate in children.
Clin Pharmacokinet. 1984 Jul-Aug;9(4):335-48. doi: 10.2165/00003088-198409040-00003.
3
Methotrexate and methotrexate polyglutamates in human sarcoma metastases after high-dose methotrexate therapy.
Klin Wochenschr. 1983 Nov 2;61(21):1089-94. doi: 10.1007/BF01496470.
4
Methotrexate kinetics in myeloid bone marrow cells and peripheral neutrophils.
甲氨蝶呤在髓系骨髓细胞和外周血中性粒细胞中的动力学。
Cancer Chemother Pharmacol. 1987;19(1):42-6. doi: 10.1007/BF00296254.
5
Methotrexate pharmacokinetics in age-fractionated erythrocytes.甲氨蝶呤在按年龄分层的红细胞中的药代动力学。
Cancer Chemother Pharmacol. 1986;18(3):203-7. doi: 10.1007/BF00273386.
6
Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment.急性淋巴细胞白血病患儿维持治疗期间红细胞甲氨蝶呤的药代动力学
Cancer Chemother Pharmacol. 1986;16(2):190-3. doi: 10.1007/BF00256175.
7
In vivo decline of methotrexate and methotrexate polyglutamates in age-fractionated erythrocytes.甲氨蝶呤及甲氨蝶呤多聚谷氨酸盐在按年龄分层的红细胞中的体内衰减情况。
Cancer Chemother Pharmacol. 1988;21(2):150-5. doi: 10.1007/BF00257363.
8
Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia.急性淋巴细胞白血病患儿每周低剂量口服甲氨蝶呤治疗期间及治疗后红细胞中甲氨蝶呤及其聚谷氨酸衍生物的情况
Cancer Chemother Pharmacol. 1988;21(2):145-9. doi: 10.1007/BF00257362.