Zeng Y, Zhong J M, de Thé G, Wu S H, Hou Y T, Miao X Q
Intervirology. 1982;18(1-2):33-7. doi: 10.1159/000149301.
The purpose of this study was to determine the antiviral effect of human leukocyte interferon on Epstein-Barr virus (EBV) viral capsid antigen (VCA) and early antigen (EA) induction in B95-8 and Raji cells. Interferon made at the Institute of Virology, Beijing, and that provided by Dr. Cantell gave unexpected results. Both interferon preparations markedly enhanced spontaneous VCA and EA induction in B95-8 cells and EA induction in Raji cells simultaneously treated with croton oil and n-butyrate. Interferon treatment alone had no effect on EA induction in Raji cells. Thus, the effect of interferon on EA and VCA induction was related to the type of EBV infection, i.e., productive or latent. The enhancing activity of interferon could only be partially inhibited by retinoid 7901. It is suggested that the mechanism for enhancement of EA induction by interferon is different from that of EA induction in Raji cells by croton oil and n-butyrate.
本研究的目的是确定人白细胞干扰素对B95 - 8和Raji细胞中EB病毒（EBV）病毒衣壳抗原（VCA）和早期抗原（EA）诱导的抗病毒作用。北京病毒研究所制备的干扰素以及坎特尔博士提供的干扰素给出了意想不到的结果。两种干扰素制剂均显著增强了B95 - 8细胞中VCA和EA的自发诱导，以及在用巴豆油和正丁酸盐同时处理的Raji细胞中EA的诱导。单独使用干扰素对Raji细胞中EA的诱导没有影响。因此，干扰素对EA和VCA诱导的作用与EBV感染的类型有关，即生产性感染或潜伏性感染。类视黄醇7901只能部分抑制干扰素的增强活性。提示干扰素增强EA诱导的机制与巴豆油和正丁酸盐诱导Raji细胞中EA的机制不同。
