Dorr R T, Peng Y M, Alberts D S
J Med. 1982;13(1-2):121-30.
Three separate in vitro admixture experiments were accomplished with bleomycin and other common parenteral medications. Bleomycin was assayed by a radioimmunoassay procedure. Bleomycin was found to be compatible with a majority of drugs including the aminoglycoside antibiotics, the vinca alkaloid antineoplastics, the antimetabolite fluorouracil, several phosphate salt corticosteroids, diphenhydramine and the anticoagulant heparin sulfate. Incompatible admixtures include the acidic cephalosporin and penicillin-derived antibiotics, the antineoplastics, methotrexate, and mitomycin C, the sodium succinate salt of hydrocortisone as well as ascorbic acid (vitamin C).
使用博来霉素和其他常用的肠胃外药物进行了三项独立的体外混合实验。通过放射免疫分析程序对博来霉素进行检测。发现博来霉素与大多数药物相容，包括氨基糖苷类抗生素、长春花生物碱类抗肿瘤药、抗代谢药氟尿嘧啶、几种磷酸盐皮质类固醇、苯海拉明和抗凝剂硫酸肝素。不相容的混合药物包括酸性头孢菌素和青霉素衍生抗生素、抗肿瘤药甲氨蝶呤和丝裂霉素C、氢化可的松琥珀酸钠盐以及抗坏血酸（维生素C）。
