McRae M P, King J C
Am J Hosp Pharm. 1976 Oct;33(10):1010-3.
Through the use of absorption spectroscopy and visual observations, the compatibility of selected oncologic, antibiotic and corticosteroid drugs in intravenous admixtures was determined. The six drugs used in this study were methotrexate sodium, prednisolone sodium phosphate, sodium cephalothin, 5-fluorouracil, cytarabine and vincristine sulfate. These were cross-matched in pairs, using 5% dextrose injection as the vehicle. By obtaining the ultraviolet absorption spectrum of each of the drugs alone in the 5% dextrose injection, reference of standard spectra were obtained which could be used as a comparison for the spectra of the drugs in admixture. This comparison permitted detection of any alterations in the spectrum which would suggest chemical (nonvisual) incompatibility. Of the 13 combinations examined, four pairs appeared to be chemically incompatible. These were: 5-fluorouracil and methotrexate sodium; 5-fluorouracil and cytarabine; prednisolone sodium phosphate and methotrexate sodium; and methotrexate sodium and cytarabine.
通过吸收光谱法和肉眼观察，确定了选定的肿瘤药物、抗生素和皮质类固醇药物在静脉混合液中的相容性。本研究中使用的六种药物分别是甲氨蝶呤钠、泼尼松龙磷酸钠、头孢噻吩钠、5-氟尿嘧啶、阿糖胞苷和硫酸长春新碱。以5%葡萄糖注射液作为溶媒，将这些药物两两交叉配伍。通过获取每种药物在5%葡萄糖注射液中的紫外吸收光谱，得到了标准光谱参考，可用于与混合液中药物的光谱进行比较。这种比较能够检测光谱中的任何变化，这些变化可能表明存在化学（非肉眼可见）不相容性。在所检测的13种组合中，有四对似乎存在化学不相容性。它们分别是：5-氟尿嘧啶与甲氨蝶呤钠；5-氟尿嘧啶与阿糖胞苷；泼尼松龙磷酸钠与甲氨蝶呤钠；以及甲氨蝶呤钠与阿糖胞苷。
