Krahn V
J Neurol. 1981;226(1):43-52. doi: 10.1007/BF00313317.
Pleocytosis in cerebrospinal fluid and infiltration of the leptomeningeal tissue have been studied after injection of ferritin into the subarachnoid space (SAS) of cats. The most important source of granulocytes in the leptomeninges are the relatively large veins of the pia mater, which have very thin walls. Passing between the lining cells of the pia mater the granulocytes leave the connective tissue space of the pia mater and reach the SAS. Leukodiapedesis has also been observed in veins crossing the SAS. During this process, gaps between the lining cells of the perivascular leptomeningeal sheath may develop. There are two possible ways for the granulocytes to pass from the vascular pia mater to the avascular arachnoidea: either they migrate actively on the surface of the leptomeningeal trabeculae or they reach the arachnoidea passively by the circulation of the cerebrospinal fluid. Leukodiapedesis in the vessels of the dura mater occurs relatively seldom and would not be able to cause the occasionally massive infiltration of the arachnoidea.
在将铁蛋白注入猫的蛛网膜下腔（SAS）后，对脑脊液中的细胞增多以及软脑膜组织的浸润情况进行了研究。软脑膜中粒细胞的最重要来源是软膜相对较大的静脉，其壁非常薄。粒细胞穿过软膜的衬里细胞，离开软膜的结缔组织间隙并到达蛛网膜下腔。在穿过蛛网膜下腔的静脉中也观察到了白细胞渗出。在此过程中，血管周围软脑膜鞘的衬里细胞之间可能会形成间隙。粒细胞从血管丰富的软膜进入无血管的蛛网膜有两种可能的方式：要么它们在软脑膜小梁表面主动迁移，要么它们通过脑脊液循环被动到达蛛网膜。硬脑膜血管中的白细胞渗出相对较少发生，并且无法导致偶尔出现的蛛网膜大量浸润。
