Platou E S, Smiseth O A, Refsum H, Rouleau J L, Chuck L H
J Cardiovasc Pharmacol. 1982 Jul-Aug;4(4):645-51. doi: 10.1097/00005344-198207000-00017.
We investigated the hemodynamic and inotropic effects of the new class III antiarrhythmic drug melperone. In eight pentobarbital-anesthetized dogs, the effects of intravenous melperone 0.5, 2.5, and 12.5 mg/kg-1 were tested. During atrial pacing we measured cardiac output (CO), mean aortic blood pressure (MAP), right (RV) and left (LV) ventricular pressures, and LV dP/dt. In six RV papillary muscles isolated from cats and suspended in a muscle bath containing Krebs-Henseleit solution, we studied the direct effects of melperone 10(8)-5 X 10(-5) M. Administration of melperone decreased total peripheral resistance, MAP, RV and LV systolic and end-diastolic pressures, while CO remained unchanged. Melperone increased LV dP/dtmax. The contractile force (F) and dF/dtmax of the isolated ventricular muscle preparations increased slightly with increasing concentrations of melperone, up to 10(-5) M. In conclusion, melperone has vasodilator and slight positive inotropic effects in addition to its class III antiarrhythmic effect.
我们研究了新型III类抗心律失常药物美哌隆的血流动力学和变力作用。在八只戊巴比妥麻醉的犬中，测试了静脉注射0.5、2.5和12.5mg/kg-1美哌隆的效果。在心房起搏期间，我们测量了心输出量（CO）、平均主动脉血压（MAP）、右心室（RV）和左心室（LV）压力以及LV dP/dt。在从猫分离并悬浮于含有克雷布斯-亨塞尔特溶液的肌肉浴中的六块RV乳头肌中，我们研究了10(8)-5×10(-5)M美哌隆的直接作用。美哌隆给药降低了总外周阻力、MAP、RV和LV收缩压及舒张压，而CO保持不变。美哌隆增加了LV dP/dtmax。离体心室肌制备物的收缩力（F）和dF/dtmax随美哌隆浓度增加至10(-5)M而略有增加。总之，美哌隆除具有III类抗心律失常作用外，还具有血管舒张和轻微的正性肌力作用。
