Smiseth O A, Platou E S, Refsum H, Mjøs O D
Cardiovasc Res. 1981 Dec;15(12):724-30. doi: 10.1093/cvr/15.12.724.
Haemodynamic and metabolic effects of the new antiarrhythmic drug melperone were studied during acute ischaemic left ventricular failure in closed-chest anaesthetized dogs. Embolisation of the left main coronary artery with 50 micrometer plastic microspheres induced severe depression of left ventricular performance as evidenced by a marked increase in left ventricular end-diastolic pressure and a marked reduction in the maximum rate of left ventricular pressure rise (LVdP/dtmax), cardiac output, and stroke volume. Six dogs received intravenous melperone 1.0 and 2.5 mg . kg-1 (cumulative dose) 90 and 115 min after the embolisation, respectively. Six other dogs received no treatment and served as controls. Melperone effected a marked reduction in left ventricular end-diastolic pressure, a slight but transient increase in LVdP/dtmax, a moderate reduction in heart rate, a moderate reduction in mean aortic blood pressure and total peripheral resistance and a moderate increase in stroke volume. Melperone moderately decreased myocardial O2-consumption, while myocardial lactate uptake remained unchanged. In conclusion, in contrast to commonly used antiarrhythmic drugs which may all induce cardiodepression, melperone improved left ventricular function in dogs with acute ischaemic left ventricular failure.
在开胸麻醉犬急性缺血性左心室衰竭期间，研究了新型抗心律失常药物美哌隆的血流动力学和代谢效应。用50微米的塑料微球栓塞左主冠状动脉可导致左心室功能严重下降，表现为左心室舒张末期压力显著升高，左心室压力上升最大速率（LVdP/dtmax）、心输出量和每搏输出量显著降低。六只犬分别在栓塞后90分钟和115分钟静脉注射美哌隆1.0和2.5mg·kg-1（累积剂量）。另外六只犬未接受治疗作为对照。美哌隆可使左心室舒张末期压力显著降低，LVdP/dtmax轻微但短暂升高，心率适度降低，平均主动脉血压和总外周阻力适度降低，每搏输出量适度增加。美哌隆适度降低心肌耗氧量，而心肌乳酸摄取保持不变。总之，与可能都会引起心脏抑制的常用抗心律失常药物不同，美哌隆可改善急性缺血性左心室衰竭犬的左心室功能。
