Walter P, Blobel G
Nature. 1982 Oct 21;299(5885):691-8. doi: 10.1038/299691a0.
In addition to its previously characterized, six different polypeptide components, signal recognition protein--which functions in protein translocation across and integration into the endoplasmic reticulum membrane--contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle.
除了先前已鉴定的六种不同多肽成分外，信号识别蛋白（在蛋白质跨内质网膜转运并整合到内质网膜的过程中发挥作用）还包含一个7S RNA分子。该RNA与细胞质中的小7SL RNA密切相关，并且对于信号识别蛋白的结构和功能特性均是必需的——因此我们将其重新命名为信号识别颗粒。
