Saigal S, Lunyk O, Larke R P, Chernesky M A
Am J Dis Child. 1982 Oct;136(10):896-901. doi: 10.1001/archpedi.1982.03970460026006.
Infants with congenital cytomegalovirus (CMV) infection were identified through urine cultures of 15,212 consecutive neonates and studied prospectively to determine whether their neurodevelopmental and audiologic status was different from that of matched uninfected control subjects. Of 64 children with congenital CMV infection, three died, 11 could not be located for follow-up, one had quadriplegic cerebral palsy, and seven had varying degrees of sensorineural hearing loss. All matched control subjects were normal neurologically, and none of them had sensorineural hearing impairment. The Stanford-Binet test revealed scores within the normal range, at 3 and 5 years of age, for both children with CMV infection and matched control subjects, as did the preschool assessment (Wide Range Achievement Test) in children older than 5 years. However, in children with CMV infection, the home environment was less stimulating, discipline and punishment were more readily implemented, and behavioral problems were significantly greater than in the matched control subjects.
通过对15212名连续新生儿的尿液培养物进行检测，识别出先天性巨细胞病毒（CMV）感染的婴儿，并对其进行前瞻性研究，以确定他们的神经发育和听力状况是否与匹配的未感染对照受试者不同。在64名先天性CMV感染儿童中，3名死亡，11名无法找到进行随访，1名患有四肢瘫痪型脑瘫，7名有不同程度的感音神经性听力损失。所有匹配的对照受试者神经功能均正常，且均无感音神经性听力障碍。斯坦福-比奈测试显示，CMV感染儿童和匹配的对照受试者在3岁和5岁时的得分均在正常范围内，5岁以上儿童的学前评估（广泛成就测试）结果也是如此。然而，CMV感染儿童的家庭环境刺激性较小，更容易实施纪律和惩罚，行为问题也明显多于匹配的对照受试者。
