Melia W M, Nunnerley H B, Johnson P J, Williams R
Br J Cancer. 1982 Sep;46(3):331-9. doi: 10.1038/bjc.1982.208.
Thirty patients with symptoms of the carcinoid syndrome and other symptoms not controlled by pharmacological agents were analysed with respect to the value of various treatment measures used. Tumour devascularization was carried out in 11 patients, either by surgical ligation of the main hepatic artery (6) or by percutaneous arterial embolization (5). The latter was shown to be the safer technique, both with respect to initial morbidity/mortality and other side effects. Control of flushing and diarrhoea was achieved in 80% and the technique was also repeated on one occasion with success when symptoms recurred. The use of cytotoxic drugs alone, including 5-fluorouracil, cyclophosphamide and Adriamycin produced symptomatic relief in only 4 of the 22 patients treated. They should only be considered if devascularization by arterial embolization proves impossible or cannot be repeated when symptoms recur.
对30例患有类癌综合征症状且其他症状无法通过药物控制的患者，分析了所采用的各种治疗措施的价值。11例患者进行了肿瘤去血管化治疗，其中6例通过手术结扎肝总动脉，5例通过经皮动脉栓塞。结果表明，就初始发病率/死亡率和其他副作用而言，后者是更安全的技术。80%的患者潮红和腹泻症状得到控制，当症状复发时，该技术还成功重复使用了一次。单独使用细胞毒性药物，包括5-氟尿嘧啶、环磷酰胺和阿霉素，在接受治疗的22例患者中只有4例症状得到缓解。只有当动脉栓塞去血管化证明不可能或症状复发时无法重复进行时，才应考虑使用细胞毒性药物。
